VIP and PACAP receptors in GtoPdb v.2023.1

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating (PACAP) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Intestinal Peptide Receptors [65, 66]) are activated endogenous peptides VIP, PACAP-38, PACAP-27, histidine isoleucineamide (PHI), methionineamide (PHM) valine (PHV). VPAC1 VPAC2 display comparable affinity for PACAP peptides, PACAP-27 whereas PACAP-38 >100 fold more potent than VIP agonists of most isoforms PAC1 receptor. However, one splice variant human receptor has been reported to respond with [30]. PG 99-465 [117] used a selective antagonist in number physiological studies, but have significant activity at [36]. The agonist maxadilan, was extracted from salivary glands sand flies (Lutzomyia longipalpis) no sequence homology or [118]. Two deletion variants M65 [183] Max.d.4 [119] be antagonists, these not extensively characterised.